Recombinant Human HNF1 beta protein (ab116782)

Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP35680
    • SpeciesHuman
    • SequenceVRKQREILRQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQSHGPGQSDDA CSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAE CLQRG
    • Molecular weight37 kDa including tags
    • Amino acids173 to 277

Associated products

Specifications

Our Abpromise guarantee covers the use of ab116782 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

    ELISA

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • FJHN
    • Hepatocyte nuclear factor 1 beta
    • Hepatocyte nuclear factor 1-beta
    • HNF 1B
    • HNF 2
    • HNF-1-beta
    • HNF-1B
    • HNF1 beta
    • HNF1 homeobox B
    • HNF1B
    • HNF1B_HUMAN
    • HNF1beta
    • HNF2
    • Homeoprotein LF B3
    • Homeoprotein LFB3
    • HPC11
    • LF B3
    • LFB3
    • MODY 5
    • MODY5
    • TCF 2
    • TCF 2 protein
    • TCF-2
    • TCF2
    • TCF2 protein
    • Transcription factor 2
    • Transcription factor 2 hepatic
    • Variant hepatic nuclear factor
    • Variant hepatic nuclear factor 1
    • VHNF 1
    • vHNF1
    see all
  • FunctionTranscription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
  • Involvement in diseaseDefects in HNF1B are the cause of renal cysts and diabetes syndrome (RCAD) [MIM:137920]; also called maturity-onset diabetes of the young type 5 (MODY5) or familial hypoplastic glomerulocystic kidney disease (GCKD). RCAD is an autosomal dominant disorder comprising non-diabetic renal disease resulting from abnormal renal development, and diabetes, which in some cases occurs earlier than age 25 years and is thus consistent with a diagnosis of maturity-onset diabetes of the young (MODY5). The renal disease is highly variable and includes renal cysts, glomerular tufts, aberrant nephrogenesis, primitive tubules, irregular collecting systems, oligomeganephronia, enlarged renal pelves, abnormal calyces, small kidney, single kidney, horseshoe kidney, and hyperuricemic nephropathy.
    Defects in HNF1B may be rare genetic risk factor contributing to the development of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.
    Defects in HNF1B may be a cause of susceptibility to prostate cancer hereditary type 11 (HPC11) [MIM:611955]. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
  • Sequence similaritiesBelongs to the HNF1 homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • Cellular localizationNucleus.
  • Information by UniProt

Recombinant Human HNF1 beta protein images

  • 12.5% SDS-PAGE showing ab116782 at approximately 37.29kDa.
    Stained with Coomassie Blue.

References for Recombinant Human HNF1 beta protein (ab116782)

ab116782 has not yet been referenced specifically in any publications.

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