Recombinant Human hnRNP A1 protein (ab123212)

Overview

  • Product name
    Recombinant Human hnRNP A1 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSMSKSESP KEPEQLRKLF IGGLSFETTD ESLRSHFEQW GTLTDCVVMR DPNTKRSRGF GFVTYATVEE VDAAMNARPH KVDGRVVEPK RAVSREDSQR PGAHLTVKKI FVGGIKEDTE EHHLRDYFEQ YGKIEVIEIM TDRGSGKKRG FAFVTFDDHD SVDKIVIQKY HTVNGHNCEV RKALSKQEMA SASSSQRGRS GSGNFGGGRG GGFGGNDNFG RGGNFSGRGG FGGSRGGGGY GGSGDGYNGF GNDGSNFGGG GSYNDFGNYN NQSSNFGPMK GGNFGGRSSG PYGGGGQYFA KPRNQGGYGG SSSSSSYGSG RRF
    • Molecular weight
      37 kDa including tags
    • Amino acids
      1 to 320
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab123212 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry
    MALDI-TOF
  • Purity
    > 85 % SDS-PAGE.
    ab123212 was purified using conventional chromatography and is > 85% pure by SDS - PAGE.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 40% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names
    • HNRNPA 1
    • Helix destabilizing protein
    • Helix-destabilizing protein
    • Heterogeneous nuclear ribonucleoprotein A1
    • Heterogeneous nuclear ribonucleoprotein A1B protein
    • Heterogeneous nuclear ribonucleoprotein B2 protein
    • Heterogeneous nuclear ribonucleoprotein core protein A1
    • hnRNP A1
    • hnRNP core protein A1
    • HNRNPA1
    • HNRPA1
    • MGC102835
    • Nuclear ribonucleoprotein particle A1 protein
    • ROA1_HUMAN
    • Single strand DNA binding protein UP1
    • Single strand RNA binding protein
    • Single-strand RNA-binding protein
    see all
  • Function
    Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.
  • Sequence similarities
    Contains 2 RRM (RNA recognition motif) domains.
  • Post-translational
    modifications
    Arg-194, Arg-206 and Arg-225 are dimethylated, probably to asymmetric dimethylarginine.
    Sumoylated.
  • Cellular localization
    Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent manner.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab123212 (3 µg)

References

ab123212 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you for contacting us.

Regrettably, the biological activity of this product has not yet been tested. Although it is scheduled to be tested eventually, we can’t give you a specific date on when we will have the results.
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