Recombinant Human HP1 alpha protein (ab124602)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP45973
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MGSHMGKKTK RTADSSSSED EEEYVVEKVL DRRVVKGQVE YLLKWKGFSE EHNTWEPEKN LDCPELISEF MKKYKKMKEG ENNKPREKSE SNKRKSNFSN SADDIKSKKK REQSNDIARG FERGLEPEKI IGATDSCGDL MFLMKWKDTD EADLVLAKEA NVKCPQIVIA FYEERLTWHA YPEDAENKEK ETAKS
    • Molecular weight25 kDa including tags
    • Amino acids1 to 191
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab124602 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity> 90 % SDS-PAGE.
    ab124602 is purified by using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 30% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names
    • Antigen p25
    • CBX5
    • CBX5_HUMAN
    • CG8409
    • Chromobox 5
    • Chromobox homolog 5
    • Chromobox homolog 5 (HP1 alpha homolog, Drosophila)
    • Chromobox protein homolog 5
    • Epididymis luminal protein 25
    • HEL25
    • Heterochromatin protein 1
    • Heterochromatin protein 1 alpha
    • Heterochromatin protein 1 homolog alpha
    • HP1
    • HP1 alpha
    • HP1 alpha homolog
    • HP1A
    • HP1Hs alpha
    • Su(var)205
    see all
  • FunctionComponent of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
  • Sequence similaritiesContains 2 chromo domains.
  • Post-translational
    modifications
    Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
    Ubiquitinated.
  • Cellular localizationNucleus. Chromosome. Chromosome > centromere. Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.
  • Information by UniProt

Recombinant Human HP1 alpha protein images

  • 15% SDS-PAGE showing ab124602 (3 µg).

References for Recombinant Human HP1 alpha protein (ab124602)

ab124602 has not yet been referenced specifically in any publications.

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