Recombinant human hPDE4D2 protein (ab80335)

Overview

  • Product nameRecombinant human hPDE4D2 protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab80335 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activitySpecific Activity: 36365 pmol/min/µg.
  • Applications

    SDS-PAGE

    Functional Studies

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • 9630011N22Rik
    • cAMP specific 3' 5' cyclic phosphodiesterase 4D
    • cAMP specific phosphodiesterase 4D
    • cAMP specific phosphodiesterase PDE4D
    • cyclic AMP phosphodiesterase
    • DPDE3
    • Dunce like phosphodiesterase E3
    • HSPDE4D
    • PDE4D
    • PDE4DN2
    • Phosphodiesterase 4D cAMP specific
    • Phosphodiesterase E3 dunce homolog Drosophila
    • STRK 1
    • STRK1
    see all
  • RelevanceCyclic AMP-dependent phosphodiesterase type D (PDE4D) family is comprised of 5 variants (PDE4D1, D2, D3, D4 and D5). One or more PDE4D subtype variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanism involved protein protein interactions with cytoskeletal scaffolding proteins.
  • Cellular localizationCytoplasm. Membrane. Cytoplasm; cytoskeleton. Centrosome. Note= Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome

Recombinant human hPDE4D2 protein images

  • 10% SDS-PAGE showing ab80335 at approximately 103kDa (4µg).

References for Recombinant human hPDE4D2 protein (ab80335)

ab80335 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"