This product is an active protein and may elicit a biological response in vivo, handle with caution.
cAMP specific 3' 5' cyclic phosphodiesterase 4D
cAMP specific phosphodiesterase 4D
cAMP specific phosphodiesterase PDE4D
cyclic AMP phosphodiesterase
Dunce like phosphodiesterase E3
Phosphodiesterase 4D cAMP specific
Phosphodiesterase E3 dunce homolog Drosophila
RelevanceCyclic AMP-dependent phosphodiesterase type D (PDE4D) family is comprised of 5 variants (PDE4D1, D2, D3, D4 and D5). One or more PDE4D subtype variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanism involved protein protein interactions with cytoskeletal scaffolding proteins.
Cellular localizationCytoplasm. Membrane. Cytoplasm; cytoskeleton. Centrosome. Note= Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome
Recombinant human hPDE4D2 protein images
SDS-PAGE - hPDE4D2 protein (Active) (ab80335)
10% SDS-PAGE showing ab80335 at approximately 103kDa (4µg).
References for Recombinant human hPDE4D2 protein (ab80335)
has not yet been referenced specifically in any publications.
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