The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. purification checked by SDS Page and HPLC.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Endotoxin level: < 0.1 ng per µg of HRG beta-1
ReconstitutionReconstitute in water to a concentration of 0.1-1.0 mg/ml.
Acetylcholine receptor inducing activity
Breast cancer cell differentiation factor p45
glial growth factor
heregulin, alpha (45kD, ERBB2 p185 activator)
HRG beta 1A
neu differentiation factor
sensory and motor neuron derived factor
RelevanceHRG beta 1 is an isoform from the Neuregulin/Heregulin family of structurally related polypeptide growth factors which are derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.
HRG1-ß1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. Although HRG1-ß1 biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility promoting factor (AMF).
References for Recombinant Human HRG beta 1 protein (ab55742)
has not yet been referenced specifically in any publications.
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