Recombinant Human HRG beta 1 protein (ab55742)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceSHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQ NYVM ASFYKHLGIE FMEAE

Specifications

Our Abpromise guarantee covers the use of ab55742 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Purity> 98 % SDS-PAGE.
    purification checked by SDS Page and HPLC.
  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Endotoxin level: < 0.1 ng per µg of HRG beta-1

  • ReconstitutionReconstitute in water to a concentration of 0.1-1.0 mg/ml.

General Info

  • Alternative names
    • Acetylcholine receptor inducing activity
    • ARIA
    • Breast cancer cell differentiation factor p45
    • GGF
    • GGF2
    • glial growth factor
    • Heregulin
    • Heregulin beta1
    • heregulin, alpha (45kD, ERBB2 p185 activator)
    • HGL
    • HRG
    • HRG beta 1A
    • HRG1
    • HRGA
    • NDF
    • neu differentiation factor
    • Neuregulin 1
    • NRG1
    • sensory and motor neuron derived factor
    • SMDF
    see all
  • RelevanceHRG beta 1 is an isoform from the Neuregulin/Heregulin family of structurally related polypeptide growth factors which are derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells. HRG1-ß1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. Although HRG1-ß1 biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility promoting factor (AMF).
  • Cellular localizationSecreted

References for Recombinant Human HRG beta 1 protein (ab55742)

ab55742 has not yet been referenced specifically in any publications.

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