Recombinant Human HSD17B8 protein (ab105611)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MASQLQNRLR SALALVTGAG SGIGRAVSVR LAGEGATVAA CDLDRAAAQE TVRLLGGPGS KEGPPRGNHA AFQADVSEAR AARCLLEQVQ ACFSRPPSVV VSCAGITQDE FLLHMSEDDW DKVIAVNLKG TFLVTQAAAQ ALVSNGCRGS IINISSIVGK VGNVGQTNYA ASKAGVIGLT QTAARELGRH GIRCNSVLPG FIATPMTQKV PQKVVDKITE MIPMGHLGDP EDVADVVAFL ASEDSGYITG TSVEVTGGLF M
    • Molecular weight
      29 kDa including tags
    • Amino acids
      1 to 261
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab105611 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    > 95 % SDS-PAGE.
    Purified using conventional chromatography.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 40% Glycerol, 20mM Tris HCl, 150mM Sodium chloride, pH 8.0

General Info

  • Alternative names
    • 17 beta HSD 8
    • 17 beta hydroxysteroid dehydrogenase 8
    • 17-beta-HSD 8
    • 17-beta-hydroxysteroid dehydrogenase 8
    • 17-beta-hydroxysteroid dehydrogenase VIII
    • 3-oxoacyl-[acyl-carrier-protein] reductase
    • 3-oxoacyl-acyl-carrier protein reductase, E. coli, homolog of
    • Beta ketoacyl [acyl carrier protein] reductase like
    • D6S2245E
    • DHB8_HUMAN
    • dJ1033B10.9
    • Estradiol 17 beta dehydrogenase 8
    • Estradiol 17-beta-dehydrogenase 8
    • Estrogen 17 oxidoreductase
    • FABG
    • FabG, E. coli, homolog of
    • FabG-like
    • FABGL
    • H2 KE6
    • H2-KE6
    • HKE6
    • HSD17B8
    • Hydroxysteroid (17 beta) dehydrogenase 8
    • Ke-6
    • KE6
    • KE6, mouse homolog of
    • Protein Ke6
    • Really interesting new gene 2 protein
    • RING2
    • SDR30C1
    • Short chain dehydrogenase/reductase family 30C member 1
    • Testosterone 17 beta dehydrogenase 8
    • Testosterone 17-beta-dehydrogenase 8
    see all
  • Function
    NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria.
  • Tissue specificity
    Highly expressed in placenta, liver and pancreas, lower in the skeletal muscle and kidney. Widely expressed.
  • Pathway
    Steroid biosynthesis; estrogen biosynthesis.
    Lipid metabolism; fatty acid biosynthesis.
  • Sequence similarities
    Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Cellular localization
    Mitochondrion matrix.
  • Information by UniProt

Images

  • 15% SDS PAGE analysis of ab105611 (3 µg).

References

ab105611 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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