This product is an active protein and may elicit a biological response in vivo, handle with caution.
3 alpha HSD1
3-alpha-hydroxysteroid dehydrogenase type I
Aldo keto reductase family 1 member C4
Aldo-keto reductase family 1 member C4
Dihydrodiol dehydrogenase 4
FunctionCatalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
Tissue specificityLiver specific.
Sequence similaritiesBelongs to the aldo/keto reductase family.
Post-translational modificationsThe N-terminus is blocked.