Recombinant Human HSD3B2 protein (ab114767)

Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP26439
    • SpeciesHuman
    • SequenceALDKAFRPELREEFSKLQNRTKLTVLEGDILDEPFLKRACQDVSVVIHTA CIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVFIYT
    • Molecular weight36 kDa including tags
    • Amino acids33 to 122

Specifications

Our Abpromise guarantee covers the use of ab114767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 µg/ul.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 3 beta HSD adrenal and gonadal type
    • 3 beta HSD II
    • 3 beta HSD type II
    • 3 beta hydroxy 5 ene steroid dehydrogenase
    • 3 beta hydroxy Delta(5) steroid dehydrogenase
    • 3 beta hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
    • 3 beta-hydroxysteroid dehydrogenase type II, delta 5-delta 4-isomerase type II, 3 beta-HSD type II
    • 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II
    • 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
    • 3-beta-HSD II
    • 3-beta-hydroxy-5-ene steroid dehydrogenase
    • 3-beta-hydroxy-Delta(5)-steroid dehydrogenase
    • 3BHS2_HUMAN
    • ADRENAL HYPERPLASIA II
    • beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
    • delta 5 delta 4 isomerase type II
    • Delta-5-3-ketosteroid isomerase
    • HSD3B
    • HSD3B2
    • HSDB
    • HSDB3B
    • hydroxy delta 5 steroid dehydrogenase, 3 beta and steroid delta isomerase 2
    • Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
    • Progesterone reductase
    • SDR11E2
    • short chain dehydrogenase/reductase family 11E, member 2
    • Steroid Delta-isomerase
    see all
  • Function3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
  • Tissue specificityExpressed in adrenal gland, testis and ovary.
  • PathwayLipid metabolism; steroid biosynthesis.
  • Involvement in diseaseDefects in HSD3B2 are the cause of adrenal hyperplasia type 2 (AH2) [MIM:201810]. AH2 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: 'salt wasting' (SW, the most severe type), 'simple virilizing' (SV, less severely affected patients), with normal aldosterone biosynthesis, 'non-classic form' or late onset (NC or LOAH), and 'cryptic' (asymptomatic). In AH2, virilization is much less marked or does not occur. AH2 is frequently lethal in early life.
    Note=Mild HSD3B2 deficiency in hyperandrogenic females is associated with characteristic traits of polycystic ovary syndrome, such as insulin resistance and luteinizing hormon hypersecretion.
  • Sequence similaritiesBelongs to the 3-beta-HSD family.
  • Cellular localizationEndoplasmic reticulum membrane. Mitochondrion membrane.
  • Information by UniProt

Recombinant Human HSD3B2 protein images

  • 12.5% SDS-PAGE Stained with Coomassie Blue showing ab114767 at approximately 35.53kDa.

References for Recombinant Human HSD3B2 protein (ab114767)

ab114767 has not yet been referenced specifically in any publications.

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