The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityab78433 has ATPase activity at the time of manufacture of 3.0µM phosphate liberated/hr/µg protein in a 200µl reaction at 37°C (pH7.5) in the presence of 20ul of 1mM ATP using a Malachite Green assay.
competitive binding assays
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
DnaK type molecular chaperone HSP70 1
Epididymis secretory protein Li 103
Heat shock 70 kDa protein 1
Heat shock 70 kDa protein 1/2
Heat shock 70 kDa protein 1A/1B
Heat shock 70kDa protein 1A
Heat shock 70kDa protein 1B
Heat shock induced protein
HEL S 103
FunctionIn cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.
Tissue specificityHSPA1B is testis-specific.
Sequence similaritiesBelongs to the heat shock protein 70 family.
Cellular localizationCytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.