The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
69 kDa islet cell autoantigen
Diabetes mellitus type I autoantigen
Islet cell autoantigen 1
Islet cell autoantigen 1 (69kD)
Islet cell autoantigen 1 69kDa
Islet cell autoantigen 1 isoform
Islet cell autoantigen p69
FunctionMay play a role in neurotransmitter secretion.
Tissue specificityExpressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid.
Sequence similaritiesContains 1 AH domain.
Cellular localizationCytoplasm > cytosol. Golgi apparatus membrane. Cytoplasmic vesicle > secretory vesicle membrane. Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.