Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MEVTGDAGVP ESGEIRTLKP CLLRRNYSRE QHGVAASCLE DLRSKACDIL AIDKSLTPVT LVLAEDGTIV DDDDYFLCLP SNTKFVALAS NEKWAYNNSD GGTAWISQES FDVDETDSGA GLKWKNVARQ LKEDLSSIIL LSEEDLQMLV DAPCSDLAQE LRQSCATVQR LQHTLQQVLD QREEVRQSKQ LLQLYLQALE KEGSLLSKQE ESKAAFGEEV DAVDTGISRE TSSDVALASH ILTALREKQA PELSLSSQDL ELVTKEDPKA LAVALNWDIK KTETVQEACE WELALRLQQT QSLHSLRSIS ASKASPPGDL QNPKRARQDP T

Specifications

Our Abpromise guarantee covers the use of ab87632 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

  • Purity
    > 90 % SDS-PAGE.
    Purified by using conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8

General Info

  • Alternative names
    • A330085O09Rik
    • Caspase activated deoxyribonuclease inhibitor short form
    • DFF 1
    • DFF 45
    • DFF alpha
    • DFF-45
    • DFF1
    • DFF35
    • DFF45
    • DFFA
    • Dffa DNA fragmentation factor, alpha subunit
    • DFFA_HUMAN
    • DNA fragmentation factor 45 kDa subunit
    • DNA Fragmentation Factor Alpha Subunit
    • DNA fragmentation factor subunit alpha
    • DNA fragmentation factor, 45 kD, alpha subunit
    • DNA fragmentation factor, 45kDa, alpha polypeptide
    • DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1
    • DNA fragmentation factor, alpha subunit
    • DNAation factor 45 kDa subunit
    • H13
    • ICAD
    • ICAD L
    • ICAD S
    • Inhibitor of CAD
    • Inhibitor of Caspase Activated DNase
    • MGC143066
    • OTTHUMP00000001903
    • OTTHUMP00000001904
    • RP23 121D17.3
    see all
  • Function
    Inhibitor of the caspase-activated DNase (DFF40).
  • Sequence similarities
    Contains 1 CIDE-N domain.
  • Post-translational
    modifications
    Caspase-3 cleaves DFF45 at 2 sites to generate an active factor.
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

Images

  • ab87632 on 15% SDS-PAGE (3µg)

References

ab87632 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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