The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityab82125 supported the adhesion of more than 50% PMA-stimulated HSB2 cells to plates coated at 25µg/ml ICAM1 concentration
Endotoxin level< 0.100 Eu/µg
% SDS-PAGE. Purity is greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Antigen identified by monoclonal antibody BB2
Cell surface glycoprotein P3.58
Human rhinovirus receptor
Intercellular adhesion molecule 1
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
Major group rhinovirus receptor
Surface antigen of activated B cells, BB2
FunctionICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
Sequence similaritiesBelongs to the immunoglobulin superfamily. ICAM family. Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Post-translational modificationsMonoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.