The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml. Best used within three months from the date of receipt.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
Alpha type antiviral protein
Antiviral protein, alpha-type
Antiviral protein, beta-type
Beta type antiviral protein
Cytokine receptor class-II member 1
Cytokine receptor family 2 member 1
IFN alpha REC
IFN alpha receptor
IFN alpha/beta Receptor alpha
IFN beta receptor
IFN Interferon-beta receptor
IFN-alpha/beta receptor 1
Interferon (alpha beta and omega) receptor 1
interferon alpha and beta receptor subunit 1
Interferon alpha/beta receptor 1
Interferon alpha/beta receptor alpha chain
Interferon beta receptor 1
interferon receptor 1
Type I interferon receptor 1
FunctionAssociates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
Tissue specificityIFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.
Sequence similaritiesBelongs to the type II cytokine receptor family. Contains 3 fibronectin type-III domains.
Post-translational modificationsPhosphorylated on tyrosine residues by TYK2 tyrosine kinase.