Recombinant Human IFNAR1 protein (ab114292)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      KNLKSPQKVEVDIIDDNFILRWNRSDESVGNVTFSFDYQKTGMDNWIKLS GCQNITSTKCNFSSLKLNVYEEIKLRIRAEKENTSSWYEVDSFTPFRKAQ
    • Molecular weight
      37 kDa including tags
    • Amino acids
      28 to 127

Specifications

Our Abpromise guarantee covers the use of ab114292 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Alpha type antiviral protein
    • Antiviral protein, alpha-type
    • Antiviral protein, beta-type
    • AVP
    • Beta type antiviral protein
    • CRF2-1
    • Cytokine receptor class-II member 1
    • Cytokine receptor family 2 member 1
    • IFN alpha REC
    • IFN alpha receptor
    • IFN alpha/beta Receptor alpha
    • IFN beta receptor
    • IFN Interferon-beta receptor
    • IFN-alpha/beta receptor 1
    • IFN-R-1
    • IFNAR
    • Ifnar1
    • IFNBR
    • IFRC
    • INAR1_HUMAN
    • Interferon (alpha beta and omega) receptor 1
    • interferon alpha and beta receptor subunit 1
    • Interferon alpha/beta receptor 1
    • Interferon alpha/beta receptor alpha chain
    • Interferon beta receptor 1
    • interferon receptor 1
    • Interferon-alpha receptor
    • Type I interferon receptor 1
    see all
  • Function
    Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
  • Tissue specificity
    IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.
  • Sequence similarities
    Belongs to the type II cytokine receptor family.
    Contains 3 fibronectin type-III domains.
  • Post-translational
    modifications
    Phosphorylated on tyrosine residues by TYK2 tyrosine kinase.
  • Cellular localization
    Membrane.
  • Information by UniProt

Images

  • ab114292 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

References

ab114292 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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