It is recommended to reconstitute the lyophilized product in 200 µl sterile deionized water to a final concentration of 1 mg/ml. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% HSA or BSA) is strongly recommended for further dilution and long term storage.
Antiviral Protein Type II
Antiviral protein, type 2
AVP type II
AVP, type 2
IFN gamma R
IFN gamma R alpha
IFN gamma R1
IFN-gamma receptor 1
Immune interferon receptor 1
Immune interferon receptor for
Interferon gamma receptor 1
Interferon gamma receptor alpha chain
Interferon gamma receptor alpha chain precursor
Receptor for interferon gamma. Two receptors bind one interferon gamma dimer.
Involvement in disease
Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
Belongs to the type II cytokine receptor family. Contains 2 fibronectin type-III domains. Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
SDS-PAGE - Human IFNGR1 protein fragment (ab181887)
SDS-PAGE analysis of ab181887 stained overnight with Coomassie Blue.
Lane 1: DTT-reduced
Lane 2: Non-reduced
As a result of glycosylation, DTT-reduced protein migrates as 75-100 kDa and non-reduced protein migrates as 150-170 kDa.
This product has been referenced in:
Qiao LN et al. Effect of electroacupuncture on thermal pain threshold and expression of calcitonin-gene related peptide, substance P and ?-aminobutyric acid in the cervical dorsal root ganglion of rats with incisional neck pain. Acupunct Med35:276-283 (2017).
Read more (PubMed: 28600329) »