The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activity=>1x106 U/mg
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells is <= 1.0 ng/ml.
% SDS-PAGE. Purity by SDS PAGE is >98%.
Additional notesEndotoxin Level <0.1 ng/µg of IGF1.
For long term storage, the addition of a carrier protein is recommended.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -80°C.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Insulin like growth factor 1
Insulin like growth factor 1 (somatomedin C)
Insulin like growth factor IA
Insulin like growth factor IB
Insulin-like growth factor I
Mechano growth factor
FunctionThe insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.
Involvement in diseaseDefects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
Sequence similaritiesBelongs to the insulin family.