Overview

Description

  • NatureRecombinant
  • SourceCHO cells
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab52086 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThe ED50 as determined by the induction of IFN-γ production from murine splenocytes co-stimulated with IL-12 is <0.1 ng/ml, corresponding to a specific activity of > 1 x 107 units/mg.
  • Applications

    SDS-PAGE

    Functional Studies

  • FormLyophilised
  • Additional notesThe lyophilized human IL-12 is best-stored desiccated below 0oC. Reconstituted IL-12 should be stored at working aliquots at -20oC. This solution can then be diluted into other aqueous buffers and stored at 4oC for 1 week or –20oC for future use.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: PBS, pH 7.2-7.4

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • ReconstitutionCentrifuge the vial prior to opening. Reconstitute in 1X PBS (pH 7.2-7.4) to a concentration of 0.2 mg/ml.

General Info

  • Alternative names
    • CLMF
    • CLMF p35
    • CLMF p40
    • CLMF1
    • CLMF2
    • Cytotoxic lymphocyte maturation factor 1, p35
    • Cytotoxic lymphocyte maturation factor 2
    • Cytotoxic lymphocyte maturation factor 35 kDa subunit
    • Cytotoxic lymphocyte maturation factor 40 kDa subunit
    • IL 2 subunit p40
    • IL-12 subunit p35
    • IL-12A
    • IL-12B
    • IL12, p35 subunit
    • IL12, subunit p40
    • IL12A
    • IL12A_HUMAN
    • IL12B
    • IL35 subunit
    • Interleukin 12 alpha chain
    • Interleukin 12 beta chain
    • Interleukin 12 subunit beta
    • Interleukin 12, p40
    • Interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
    • Interleukin 12B
    • Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
    • Interleukin-12 subunit alpha
    • Natural killer cell stimulatory factor 1, 35 kD subunit
    • natural killer cell stimulatory factor 2
    • Natural killer cell stimulatory factor, 40 kD subunit
    • NF cell stimulatory factor chain 1
    • NFSK
    • NK cell stimulatory factor chain 1
    • NK cell stimulatory factor chain 2
    • NKSF
    • NKSF1
    • NKSF2
    • P35
    see all
  • FunctionCytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.
  • Sequence similaritiesBelongs to the IL-6 superfamily.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Recombinant human IL12 protein (ab52086)

ab52086 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"