The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml.
This protein is best used within three months from the date of receipt.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
IL-12 receptor subunit beta-2
IL-12R subunit beta-2
IL12 receptor beta 2
Interleukin 12 receptor beta 2
Interleukin 12 receptor beta 2 chain
Interleukin-12 receptor subunit beta-2
FunctionReceptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
Tissue specificityIsoform 2 is expressed at similar levels in both naive and activated T-cells.
Sequence similaritiesBelongs to the type I cytokine receptor family. Type 2 subfamily. Contains 5 fibronectin type-III domains.
Developmental stageMaximum levels in Th1 cells between day 3 and day 8 of activation.
DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation.
Post-translational modificationsOn IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.