The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityThe ED50 of recombinant Human IL17, as determined by the production of IL6 by NIH3T3 cells, was typically found to be 3-15 ng/ml.
% SDS-PAGE. ab119440 is purified by proprietary chromatographic techniques. Purity is > 98 % by SDS-PAGE and HPLC.
Additional notesEndotoxin level is <0.1 ng/µg.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20ºC.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionCentrifuge the vial prior to opening. Reconstitute with sterile water to a concentration of 0.1 mg/ml, the solution can then be diluted into other aqueous buffers.
For long term storage it is recommended to add a carrier protein (0.1 % HSA or BSA).
Cytotoxic T lymphocyte associated antigen 8
Cytotoxic T lymphocyte associated protein 8
Cytotoxic T lymphocyte associated serine esterase 8
Cytotoxic T-lymphocyte-associated antigen 8
Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8)
FunctionLigand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).
Tissue specificityRestricted to activated memory T-cells.
Sequence similaritiesBelongs to the IL-17 family.
Post-translational modificationsFound both in glycosylated and nonglycosylated forms.