The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityThe activity of IL17 is measured by its ability to induce IL6 production in NHDF cells. The ED50 is typically between 0.5 and 1.5 ng/ml.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.
Constituents: 10% Trehalose, 1% Human serum albumin
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionIt is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
Following reconstitution short-term storage at 4°C and longer-term storage of aliquots at -18 to -20°C is recommended. Repeated freeze thawing is not recommended.
Cytotoxic T lymphocyte associated antigen 8
Cytotoxic T lymphocyte associated protein 8
Cytotoxic T lymphocyte associated serine esterase 8
Cytotoxic T-lymphocyte-associated antigen 8
Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8)
FunctionLigand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).
Tissue specificityRestricted to activated memory T-cells.
Sequence similaritiesBelongs to the IL-17 family.
Post-translational modificationsFound both in glycosylated and nonglycosylated forms.