The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activity>1 x 107 units/mg as determined by dose-dependent stimulation of CTLL2 cells.
% SDS-PAGE. Purity >98% by SDS PAGE and HPLC sequence analysis.
Additional notesPrior to reconstitution store at +4°C.
>1 x 107 units/mg as determined by dose-dependent stimulation of CTLL2 cells.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionReconstitute with 0.1ml 0.1M acetic acid. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. We recommend that the vial is gently mixed after reconstitution.
Involved in regulation of T cell clonal expansion
T Cell Growth Factor
T-cell growth factor
FunctionProduced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Involvement in diseaseNote=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.