The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityBiological activity measured by the ability to induce IL-17 secretion by mouse splenocytes.
Endotoxin level< 0.100 Eu/µg
% SDS-PAGE. Purity greater than 95% by SDS-PAGE gel and HPLC analyses. Sterile filtered through a 0.2 micron filter.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C or -80°C. Avoid freeze / thaw cycle. Please see notes section.
Constituents: 1X PBS, pH 7.2
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionCentrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
IL 23 A
IL 23 subunit alpha
IL-23 subunit alpha
Interleukin 23 alpha subunit p19
Interleukin 23 p19 subunit
interleukin 23 subunit alpha
interleukin 23 subunit p19
interleukin six, G CSF related factor
Interleukin-23 subunit alpha
Interleukin-23 subunit p19
JKA3 induced upon T cell activation
FunctionAssociates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Tissue specificitySecreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
Sequence similaritiesBelongs to the IL-6 superfamily.
Developmental stageExpressed by newborns dendritic cells.
Cellular localizationSecreted. Secreted upon association with IL12B.