Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MKNLNPKKFS IHDQDHKVLV LDSGNLIAVP DKNYIRPEIF FALASSLSSA SAEKGSPILL GVSKGEFCLY CDKDKGQSHP SLQLKKEKLM KLAAQKESAR RPFIFYRAQV GSWNMLESAA HPGWFICTSC NCNEPVGVTD KFENRKHIEF SFQPVCKAEM SPSEVSD
    • Molecular weight
      19 kDa
    • Amino acids
      53 to 218

Associated products

Specifications

Our Abpromise guarantee covers the use of ab151873 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

    SDS-PAGE

  • Endotoxin level
    < 1.000 Eu/µg
  • Purity
    >95% by SDS-PAGE .
    Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. ab151873 was lyophilised from a 0.2 µM filtered solution.
  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C or -80°C.

    pH: 7.40
    Constituents: 99% Phosphate Buffer, 0.03% DTT, 0.88% Sodium chloride

  • Reconstitution
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Dissolve the lyophilised protein in 1X PBS. It is not recommended to reconstitute to a concentration less than 100 µg/ml.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days. For long term storage aliquot and store at < -20°C.

General Info

  • Alternative names
    • FIL1
    • FIL1 zeta
    • FIL1(ZETA)
    • FIL1Z
    • IL 1 zeta
    • IL 1F7
    • IL 1F7b (IL 1H4, IL 1H, IL 1RP1)
    • IL 1H4
    • IL 1RP1
    • IL 1X
    • IL 1X protein
    • IL-1 zeta
    • IL-1F7
    • IL-1H
    • IL-1H4
    • IL-1RP1
    • IL-1X
    • IL-37
    • IL1F7
    • IL1F7 (canonical product IL 1F7b)
    • IL1F7_HUMAN
    • IL1H4
    • IL1RP1
    • Interleukin 1 family member 7
    • interleukin 1 family, member 7 (zeta)
    • Interleukin 1 homolog 4
    • Interleukin 1 related protein
    • Interleukin 1 superfamily z
    • Interleukin 1 zeta
    • Interleukin 37
    • Interleukin-1 family member 7
    • Interleukin-1 homolog 4
    • Interleukin-1 zeta
    • Interleukin-1-related protein
    • Interleukin-23
    see all
  • Function
    Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
  • Tissue specificity
    In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.
  • Sequence similarities
    Belongs to the IL-1 family.
  • Post-translational
    modifications
    Proteolytically converted to the mature form by CASP1.
  • Cellular localization
    Cytoplasm > cytosol. Nucleus. Secreted. Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation.
  • Information by UniProt

References

ab151873 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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