Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MSFVGENSGVKMGSEDWEKDEPQCCLEDPAVSPLEPGPSLPAMNFVHTSP KVKNLNPKKFSIHDQDHKVLVLDSGNLIAVPDKNYIRPEIFFALASSLSS ASAEKGSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEKLMKLAAQKESA RRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHIE FSFQPVCKAEMSPSEVSD
    • Amino acids
      1 to 218
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab153288 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • FIL1
    • FIL1 zeta
    • FIL1(ZETA)
    • FIL1Z
    • IL 1 zeta
    • IL 1F7
    • IL 1F7b (IL 1H4, IL 1H, IL 1RP1)
    • IL 1H4
    • IL 1RP1
    • IL 1X
    • IL 1X protein
    • IL-1 zeta
    • IL-1F7
    • IL-1H
    • IL-1H4
    • IL-1RP1
    • IL-1X
    • IL-37
    • IL1F7
    • IL1F7 (canonical product IL 1F7b)
    • IL1F7_HUMAN
    • IL1H4
    • IL1RP1
    • Interleukin 1 family member 7
    • interleukin 1 family, member 7 (zeta)
    • Interleukin 1 homolog 4
    • Interleukin 1 related protein
    • Interleukin 1 superfamily z
    • Interleukin 1 zeta
    • Interleukin 37
    • Interleukin-1 family member 7
    • Interleukin-1 homolog 4
    • Interleukin-1 zeta
    • Interleukin-1-related protein
    • Interleukin-23
    see all
  • Function
    Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
  • Tissue specificity
    In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.
  • Sequence similarities
    Belongs to the IL-1 family.
  • Post-translational
    modifications
    Proteolytically converted to the mature form by CASP1.
  • Cellular localization
    Cytoplasm > cytosol. Nucleus. Secreted. Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation.
  • Information by UniProt

Images

  • ab153288 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab153288 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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