The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 25.0-150.0 ng/mL.
Endotoxin level< 0.100 Eu/µg
% SDS-PAGE. Sterile filtered. Greater than 98% pure by SDS-PAGE and HPLC analyses.
Additional notesThe biological activity of this product is determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 25.0 - 150.0 ng/ml.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionReconstitute in sterile water to 0.1 to 1.0 mg/ml.
Beta thromboglobulin like protein
C-X-C motif chemokine 8
chemokine, CXC motif, ligand 8
GCP/IL-8 protein I
GCP/IL-8 protein II
GCP/IL-8 protein III
GCP/IL-8 protein IV
GCP/IL-8 protein V
GCP/IL-8 protein VI
Granulocyte chemotactic protein 1
IL8/NAP1 form I
IL8/NAP1 form II
IL8/NAP1 form III
IL8/NAP1 form IV
IL8/NAP1 form V
IL8/NAP1 form VI
Lymphocyte-derived neutrophil-activating factor
Monocyte-derived neutrophil chemotactic factor
Monocyte-derived neutrophil-activating peptide
Neutrophil activating peptide 1
Neutrophil activating protein 1
Neutrophil-activating protein 1
Protein 3 10C
Small inducible cytokine subfamily B member 8
T cell chemotactic factor
T-cell chemotactic factor
FunctionIL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
Sequence similaritiesBelongs to the intercrine alpha (chemokine CxC) family.
Post-translational modificationsSeveral N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.