Overview

  • Product nameRecombinant Human IMPDH1 protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP20839
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MADYLISGGT GYVPEDGLTA QQLFASADGL TYNDFLILPG FIDFIADEVD LTSALTRKIT LKTPLISSPM DTVTEADMAI AMALMGGIGF IHHNCTPEFQ ANEVRKVKKF EQGFITDPVV LSPSHTVGDV LEAKMRHGFS GIPITETGTM GSKLVGIVTS RDIDFLAEKD HTTLLSEVMT PRIELVVAPA GVTLKEANEI LQRSKKGKLP IVNDCDELVA IIARTDLKKN RDYPLASKDS QKQLLCGAAV GTREDDKYRL DLLTQAGVDV IVLDSSQGNS VYQIAMVHYI KQKYPHLQVI GGNVVTAAQA KNLIDAGVDG LRVGMGCGSI CITQEVMACG RPQGTAVYKV AEYARRFGVP IIADGGIQTV GHVVKALALG ASTVMMGSLL AATTEAPGEY FFSDGVRLKK YRGMGSLDAM EKSSSSQKRY FSEGDKVKIA QGVSGSIQDK GSIQKFVPYL IAGIQHGCQD IGARSLSVLR SMMYSGELKF EKRTMSAQIE GGVHGLHSYE KRLY
    • Molecular weight58 kDa including tags
    • Amino acids1 to 514
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab97410 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF-TOF
  • Purity> 95 % SDS-PAGE.
    ab97410 is purified using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0

General Info

  • Alternative names
    • IMDH1_HUMAN
    • IMP (inosine monophosphate) dehydrogenase 1
    • IMP dehydrogenase 1
    • IMPD
    • IMPD 1
    • IMPD1
    • IMPDH 1
    • IMPDH I
    • IMPDH-I
    • Impdh1
    • Inosine 5' monophosphate dehydrogenase 1
    • Inosine monophosphate dehydrogenase 1
    • Inosine-5''-monophosphate dehydrogenase 1
    • LCA11
    • RP10
    • sWSS2608
    see all
  • FunctionRate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.
  • Tissue specificityIMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
  • PathwayPurine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.
  • Involvement in diseaseDefects in IMPDH1 are the cause of retinitis pigmentosa type 10 (RP10) [MIM:180105]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP10 inheritance is autosomal dominant.
  • Sequence similaritiesBelongs to the IMPDH/GMPR family.
    Contains 2 CBS domains.
  • Information by UniProt

Recombinant Human IMPDH1 protein images

  • 15% SDS-PAGE showing ab97410 at approximately 57.5kDa (3µg).

References for Recombinant Human IMPDH1 protein (ab97410)

ab97410 has not yet been referenced specifically in any publications.

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