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Source Escherichia coli
Amino Acid Sequence
Sequence MGSSHHHHHHSSGLVPRGSHMADYLISGGTSYVPDDGLTAQQLFNCGDGL TYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAI AMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDV FEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKN RDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNS IFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSI CITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALG ASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRY FSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
Molecular weight 58 kDa including tags
Amino acids 1 to 514
Tags His tag N-Terminus Specifications
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Purity > 90
% SDS-PAGE. ab113608 was purified using conventional chromatography.
Concentration information loading... Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Constituents: 0.32% Tris HCl, 0.03% DTT, 20% Glycerol, 0.88% Sodium chloride
IMP (inosine monophosphate) dehydrogenase 2
IMP dehydrogenase 2
Function Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.
Tissue specificity IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
Pathway Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.
Sequence similarities Belongs to the IMPDH/GMPR family. Contains 2 CBS domains.
Post-translational modifications The N-terminus is blocked.
Information by UniProt
Recombinant Human IMPDH2 protein images
References for Recombinant Human IMPDH2 protein (ab113608)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"