Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MLSPANGEQLHLVNYVEDYLDSIESLPFDLQRNVSLMREIDAKYQEILKE LDECYERFSRETDGAQKRRMLHCVQRALIRSQELGDEKIQIVSQMVELVE NRTRQVDSHVELFEAQQELGDTAGNSGKAGADRPKGEAAAQADKPNSKRS RRQRNNENRENASSNHDHDDGASGTPKEKKAKTSKKKKRSKAKAEREASP ADLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGK WYCPKCRGENEKTMDKALEKSKKERAYNR
    • Molecular weight
      57 kDa including tags
    • Amino acids
      1 to 279

Specifications

Our Abpromise guarantee covers the use of ab116858 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

    SDS-PAGE

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml. This protein is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 2610028J21Rik
    • AA407184
    • AI875420
    • Growth inhibitor ING 1
    • Growth inhibitor ING1
    • Growth inhibitory protein ING 1
    • Growth inhibitory protein ING1
    • Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds
    • ING 1
    • Ing1
    • ING1_HUMAN
    • Inhibitor of growth 1
    • Inhibitor of growth family member 1
    • Inhibitor of growth protein 1
    • mING1h
    • OTTHUMP00000018703
    • OTTHUMP00000018704
    • OTTHUMP00000018705
    • OTTHUMP00000018706
    • p24ING1c
    • p33
    • p33 ING1
    • p33ING1
    • p33ING1b
    • p33ING1c
    • p37Ing1b
    • p47
    • p47ING1a
    • Tumor suppressor ING 1
    • Tumor suppressor ING1
    see all
  • Function
    Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
  • Tissue specificity
    Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.
  • Involvement in disease
    Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck.
  • Sequence similarities
    Belongs to the ING family.
    Contains 1 PHD-type zinc finger.
  • Cellular localization
    Nucleus.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE showing ab116858 at approximately 56.76kDa and stained with Coomassie Blue.

References

ab116858 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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