Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds
Inhibitor of growth 1
Inhibitor of growth family member 1
Inhibitor of growth protein 1
Tumor suppressor ING 1
Tumor suppressor ING1
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.
Involvement in disease
Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck.
Belongs to the ING family. Contains 1 PHD-type zinc finger.