The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab171499 is purified by using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.00 Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol
ING 1 like tumor suppressor protein
ING1 like tumor suppressor protein
Inhibitor of growth 1 like
Inhibitor of growth 1 like protein
Inhibitor of growth 1-like protein
Inhibitor of growth family member 1 like
Inhibitor of growth family member 2
Inhibitor of growth protein 2
Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.
Belongs to the ING family. Contains 1 PHD-type zinc finger.
The PHD-type zinc finger domain binds to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns(5)P).
Nucleus. Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.