Recombinant Human Integrin beta 4 binding protein (ab116841)

Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP56537
    • SpeciesHuman
    • SequenceVLVGSYCVFSNQGGLVHPKTSIEDQDELSSLLQVPLVAGTVNRGSEVIAA GMVVNDWCAFCGLDTTSTELSVVESVFKLNEAQPSTIATSMRDSLIDSLT
    • Molecular weight37 kDa including tags
    • Amino acids146 to 245

Specifications

Our Abpromise guarantee covers the use of ab116841 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • b(2)gcn
    • B(2)GCN homolog
    • B4 integrin interactor
    • Binding protein of beta-4 integrin
    • CAB
    • eIF-6
    • EIF3A
    • EIF6
    • Eukaryotic translation initiation factor 3A
    • Eukaryotic translation initiation factor 6
    • IF6_HUMAN
    • ITGB4BP
    • OK/SW-cl.27
    • p27 beta 4 integrin binding protein
    • p27(BBP)
    • p27BBP
    • RP4-614O4.1
    see all
  • FunctionBinds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity.
  • Tissue specificityExpressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level).
  • Sequence similaritiesBelongs to the eIF-6 family.
  • Post-translational
    modifications
    Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
  • Cellular localizationCytoplasm. Nucleus > nucleolus. Shuttles between cytoplasm and nucleus/nucleolus.
  • Information by UniProt

Recombinant Human Integrin beta 4 binding protein images

  • 12.5% SDS-PAGE stained with Coomassie Blue showing ab116841 at approximately 36.63 kDa.

References for Recombinant Human Integrin beta 4 binding protein (ab116841)

ab116841 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"