Recombinant Human Integrin beta 7 protein (ab114398)

Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP26010
    • SpeciesHuman
    • SequencePPGVHISYESQCEGPEKREGKAEDRGQCNHVRINQTVTFWVSLQATHCLP EPHLLRLRALGFSEELIVELHTLCDCNCSDTQPQAPHCSDGQGHLQCGVC SCAPG
    • Molecular weight37 kDa
    • Amino acids401 to 505

Specifications

Our Abpromise guarantee covers the use of ab114398 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

    ELISA

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.03% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Gut homing receptor beta subunit
    • Integrin beta 7 subunit
    • Integrin beta-7
    • Integrin beta-P
    • Integrin, beta 7
    • ITB7
    • ITB7_HUMAN
    • Itgb7
    • Ly69
    • M290 IEL antigen
    see all
  • FunctionIntegrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
  • Tissue specificityExpressed in a variety of leukocyte lines.
  • Sequence similaritiesBelongs to the integrin beta chain family.
    Contains 1 VWFA domain.
  • DomainDomain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding.
  • Cellular localizationMembrane.
  • Information by UniProt

Recombinant Human Integrin beta 7 protein images

  • 12.5% SDS-PAGE analysis of ab114398, stained with Coomassie Blue.

References for Recombinant Human Integrin beta 7 protein (ab114398)

ab114398 has not yet been referenced specifically in any publications.

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