Recombinant Human Integrin linked ILK protein (ab82815)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab82815 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 2.5% Glycerol, 1% SDS, 0.1% Bromophenol blue, 50mM DTT, 25mM Tris HCl, pH 6.8

General Info

  • Alternative names
    • 59 kDa serine/threonine protein kinase
    • 59 kDa serine/threonine-protein kinase
    • DKFZp686F1765
    • Epididymis secretory protein Li 28
    • HEL S 28
    • ILK
    • ILK 1
    • ILK 2
    • ILK-1
    • ILK-2
    • ILK_HUMAN
    • ILK1
    • ILK2
    • Integrin linked Kinase
    • Integrin linked kinase 2
    • Integrin linked protein kinase
    • Integrin-linked protein kinase
    • p59
    • p59ILK
    see all
  • Function
    Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
  • Tissue specificity
    Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.
  • Sequence similarities
    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
    Contains 5 ANK repeats.
    Contains 1 protein kinase domain.
  • Domain
    A PH-like domain is involved in phosphatidylinositol phosphate binding.
  • Post-translational
    modifications
    Autophosphorylated on serine residues.
  • Cellular localization
    Cell junction > focal adhesion. Cell membrane.
  • Information by UniProt

References

ab82815 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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