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Alternative names
- 59 kDa serine/threonine protein kinase
- 59 kDa serine/threonine-protein kinase
- DKFZp686F1765
- Epididymis secretory protein Li 28
- HEL S 28
- ILK
- ILK 1
- ILK 2
- ILK-1
- ILK-2
- ILK_HUMAN
- ILK1
- ILK2
- Integrin linked Kinase
- Integrin linked kinase 2
- Integrin linked protein kinase
- Integrin-linked protein kinase
- p59
- p59ILK
see all
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Function
Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
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Tissue specificity
Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.
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Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Contains 5 ANK repeats.
Contains 1 protein kinase domain.
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Domain
A PH-like domain is involved in phosphatidylinositol phosphate binding.
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Post-translational
modifications
Autophosphorylated on serine residues.
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Cellular localization
Cell junction > focal adhesion. Cell membrane.
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Information by UniProt