Recombinant Human Interferon regulatory factor 9 protein (ab126019)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      11 kDa
    • Amino acids
      239 to 389

Specifications

Our Abpromise guarantee covers the use of ab126019 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names
    • IFN alpha responsive transcription factor subunit
    • IFN-alpha-responsive transcription factor subunit
    • Interferon regulatory factor 9
    • interferon stimulated transcription factor 3
    • Interferon-stimulated gene factor 3 gamma
    • interferon-stimulated transcription factor 3, gamma 48kDa
    • IRF 9
    • IRF-9
    • Irf9
    • IRF9_HUMAN
    • ISGF 3 gamma
    • ISGF-3 gamma
    • ISGF3
    • ISGF3 p48 subunit
    • ISGF3G
    • OTTHUMP00000164692
    • OTTHUMP00000164693
    • p48
    • Transcriptional regulator ISGF3 subunit gamma
    see all
  • Function
    Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
  • Sequence similarities
    Belongs to the IRF family.
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • Cellular localization
    Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
  • Information by UniProt

References

ab126019 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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