Recombinant human IPL-1/STK13/Aurora C protein (ab63177)

Overview

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab63177 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Specific activity 65nmol/min/mg
  • Applications

    SDS-PAGE

    Functional Studies

  • Form
    Liquid
  • Additional notes

    ab43614 (Human Myelin Basic Protein full length protein) can be utilized as a substrate for assessing Kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • AURKC
    • AIE 2
    • Aie1
    • AIE2
    • AIK 3
    • AIK3
    • ARK 3
    • ARK-3
    • ARK3
    • Aur C
    • AurC
    • Aurkc
    • AURKC_HUMAN
    • aurora 3
    • Aurora C
    • Aurora kinase C
    • aurora related kinase 3
    • Aurora-related kinase 3
    • Aurora/Ipl1 related kinase 3
    • Aurora/Ipl1-related kinase 3
    • Aurora/Ipl1/Eg2 protein 2
    • EC 2.7.11.1
    • Serine threonine protein kinase 13
    • serine/threonine kinase 13 (aurora/IPL1 like)
    • serine/threonine protein kinase aurora C
    • Serine/threonine-protein kinase 13
    • Serine/threonine-protein kinase aurora-C
    • SPGF5
    • STK13
    see all
  • Function
    May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. May also contribute to the regulation of chromosome segregation and cytokinesis.
  • Tissue specificity
    Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Expression is maximum at M phase.
  • Involvement in disease
    Defects in AURKC are the cause of male infertility with large-headed multiflagellar polyploid spermatozoa (MIMPS) [MIM:243060]; also known as infertility associated with multi-tailed spermatozoa and excessive DNA.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
    Contains 1 protein kinase domain.
  • Cellular localization
    Chromosome. Cytoplasm > cytoskeleton > spindle. Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remaines in the midbody during cytokinesis.
  • Information by UniProt

Images

  • Kinase activity plot
  • ab63177 on SDS-PAGE, MW ~61 kDa

References

ab63177 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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