This product is an active protein and may elicit a biological response in vivo, handle with caution.
Aurora kinase C
aurora related kinase 3
Aurora-related kinase 3
Aurora/Ipl1 related kinase 3
Aurora/Ipl1-related kinase 3
Aurora/Ipl1/Eg2 protein 2
Serine threonine protein kinase 13
serine/threonine kinase 13 (aurora/IPL1 like)
serine/threonine protein kinase aurora C
Serine/threonine-protein kinase 13
Serine/threonine-protein kinase aurora-C
FunctionMay play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. May also contribute to the regulation of chromosome segregation and cytokinesis.
Tissue specificityIsoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Expression is maximum at M phase.
Involvement in diseaseDefects in AURKC are the cause of male infertility with large-headed multiflagellar polyploid spermatozoa (MIMPS) [MIM:243060]; also known as infertility associated with multi-tailed spermatozoa and excessive DNA.
Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. Contains 1 protein kinase domain.
Cellular localizationChromosome. Cytoplasm > cytoskeleton > spindle. Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remaines in the midbody during cytokinesis.