Overview

Description

  • NatureRecombinant
  • SourceInsect cells
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab79739 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activitySpecific Activity: 18 pmol/min/µg.
  • Applications

    Functional Studies

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 400mM Sodium chloride, 3mM DTT, 25mM Tris HCl, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • IL-1 receptor-associated kinase 4
    • Interleukin 1 receptor associated kinase 4 mutant form 1
    • Interleukin-1 receptor-associated kinase 4
    • Interleukin1 receptor associated kinase 4
    • IPD1
    • IRAK 4
    • IRAK-4
    • IRAK4
    • IRAK4 mutated form 1
    • IRAK4_HUMAN
    • LOC 51135
    • NY REN 64
    • NY REN 64 antigen
    • NY-REN-64
    • REN64
    • Renal carcinoma antigen NY-REN-64
    see all
  • FunctionRequired for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Phosphorylates IRAK1.
  • Involvement in diseaseDefects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) [MIM:610799]. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD.
    Defects in IRAK4 are the cause of IRAK4 deficiency (IRAK4D) [MIM:607676]. IRAK4 deficiency causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.
  • Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
    Contains 1 death domain.
    Contains 1 protein kinase domain.
  • Information by UniProt

Recombinant human IRAK4 protein images

  • 10% SDS-PAGE showing ab79739 at approximately 77.5kDa (4µg).
  • Kinase assay: Specific activity 18 pmol/min/µg.

References for Recombinant human IRAK4 protein (ab79739)

ab79739 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab79739.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"