The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml. Best used within three months from the date of receipt.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
Endoplasmic reticulum (ER) to nucleus signalling 1
Endoplasmic reticulum to nucleus signaling 1
Endoplasmic reticulum-to-nucleus signaling 1
ER to nucleus signaling 1
Inositol requiring 1
Inositol requiring 1, S. cerevisiae, homolog of
Inositol requiring enzyme 1, S. cerevisiae, homolog of
Inositol requiring protein 1
inositol-requiring enzyme 1
Inositol-requiring protein 1
Serine/threonine protein kinase/endoribonuclease IRE1
FunctionSenses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Tissue specificityUbiquitously expressed. High levels observed in pancreatic tissue.
Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 KEN domain. Contains 1 protein kinase domain.