Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP05161
    • SpeciesHuman
    • SequenceMADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAKG SMGWDLTVKM LAGNEFQVSL SSSMSVSELK AQITQKIGVH AFQQRLAVHP SGVALQDRVP LASQGLGPGS TVLLVVDKCD EPLNILVRNN KGRSSTYEVR LTQTVAHLKQ QVSGLEGVQD DLFWLTFEGK PLEDQLPLGE YGLKPLSTVF MNLRLRGG
    • Molecular weight34 kDa including tags
    • Amino acids1 to 157

Associated products

Specifications

Our Abpromise guarantee covers the use of ab117165 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

    SDS-PAGE

  • Purity> 98 % SDS-PAGE.
    ab117165 is > 98.0% as determined by RP-HPLC and analysis by SDS-PAGE.
  • FormLiquid
  • Additional notesAlthough stable 4°C for 4 weeks, ab117165 should be stored desiccated below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 0.58% Sodium chloride, 0.02% DTT, 0.32% Tris HCl

General Info

  • Alternative names
    • G1P2
    • hUCRP
    • IFI 15
    • IFI15
    • Interferon alpha inducible protein
    • Interferon induced protein 15
    • Interferon induced protein IFI-15K
    • Interferon stimulated protein 15 kDa
    • Interferon, alpha-inducible protein (clone IFI-15K)
    • Interferon-induced 15 kDa protein
    • Interferon-induced 17 kDa protein
    • Interferon-induced 17-kDa/15-kDa protein
    • IP17
    • ISG 15
    • ISG15
    • ISG15 ubiquitin like modifier
    • ISG15_HUMAN
    • Ubiquitin cross-reactive protein
    • Ubiquitin-like protein ISG15
    • UCRP
    see all
  • FunctionUbiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections.
    In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy.
  • Tissue specificityDetected in lymphoid cells, striated and smooth muscle, several epithelia and neurons.
  • Sequence similaritiesContains 2 ubiquitin-like domains.
  • Cellular localizationCytoplasm. Secreted. UCRP conjugates seem to be noncovalently associated with the intermediate filaments and distributed in a punctate pattern. Also secreted.
  • Information by UniProt

References for Recombinant Human ISG15 protein (ab117165)

ab117165 has not yet been referenced specifically in any publications.

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