Recombinant human ITLN1 protein (ab109151)

Overview

Description

  • NatureRecombinant
  • SourceCHO cells
  • Amino Acid Sequence
    • AccessionQ8WWA0
    • SpeciesHuman
    • Molecular weight38 kDa including tags
    • Amino acids17 to 313
    • TagsDDDDK tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab109151 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityEnhances glucose transport mediated by insulin.
  • Applications

    Functional Studies

    SDS-PAGE

  • Endotoxin level< 0.100 Eu/µg
  • Purity> 95 % SDS-PAGE.

  • FormLyophilised
  • Additional notesAfter reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions. Enhances glucose transport mediated by insulin.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C.

    Preservative: None
    Constituents: PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • ReconstitutionReconstitute with 100µl sterile water to give a final concentration of 0.1mg/ml.

General Info

  • Alternative names
    • Endothelial lectin HL 1
    • Endothelial lectin HL-1
    • FLJ20022
    • Galactofuranose binding lectin
    • Galactofuranose-binding lectin
    • hIntL
    • HL 1
    • HL1
    • Intelectin
    • Intelectin 1
    • Intelectin-1
    • Intestinal lactoferrin receptor
    • INTL
    • ITLN
    • ITLN-1
    • ITLN1
    • ITLN1_HUMAN
    • LFR
    • Omentin
    • OTTHUMP00000027882
    see all
  • FunctionHas no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism.
  • Tissue specificityHighly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level). Highly expressed in the small intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid and, to a lesser degree, in the uterus, spleen, prostate, lymph node and thymus.
  • Sequence similaritiesContains 1 fibrinogen C-terminal domain.
  • Developmental stageFound in fetal small intestine and thymus.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localizationCell membrane. Secreted. Enriched in lipid rafts.
  • Information by UniProt

References for Recombinant human ITLN1 protein (ab109151)

ab109151 has not yet been referenced specifically in any publications.

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