The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20ºC.
Constituents: 0.32% Tris HCl, 0.58% Sodium chloride
ReconstitutionReconstitute with water to desired concentration.
GABA B receptor binding protein
GABA-B receptor-binding protein
Jak and microtubule interacting protein 1
Janus kinase and microtubule interacting protein 1
Janus kinase and microtubule-interacting protein 1
Multiple alpha-helices and RNA-linker protein 1
Multiple coiled coil GABABR1 binding protein
FunctionAssociates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.
Tissue specificityPredominantly expressed in neural tissues and lymphoid cells (at protein level). Isoform 2, isoform 3 and isoform 4 are specifically expressed in brain and retina. Isoform 1 and isoform 5 are also detected in liver, lung and skeletal muscle. Also detected in testis and to a lower extent spleen and intestine.
Sequence similaritiesBelongs to the JAKMIP family.
Cellular localizationCytoplasm > cytoskeleton. Membrane. Colocalizes with the microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent to the head of sperm cells.