Recombinant Human JTB protein (ab183230)
Key features and details
- Expression system: Escherichia coli
- Purity: > 85% SDS-PAGE
- Tags: His tag N-Terminus
- Suitable for: SDS-PAGE, MS
Description
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Product name
Recombinant Human JTB protein -
Purity
> 85 % SDS-PAGE.
ab183230 was purified using conventional chromatography techniques. -
Expression system
Escherichia coli -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MGSSHHHHHHSSGLVPRGSHMGSEAPVQEEKLSASTSNLPCWLVEEFVVA EECSPCSNFRAKTTPECGPTGYVEKITCSSSKRNEFKSCRSALMEQRL -
Predicted molecular weight
11 kDa including tags -
Amino acids
31 to 105 -
Tags
His tag N-Terminus -
Additional sequence information
NP_006685
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab183230 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
Mass Spectrometry
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Mass spectrometry
MALDI-TOF -
Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Constituents: 0.32% Tris HCl, 0.88% Sodium chloride, 0.02% DTT, 10% Glycerol (glycerin, glycerine)
General Info
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Alternative names
- hJT
- HJTB
- HSPC222
see all -
Function
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential. -
Tissue specificity
Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. -
Sequence similarities
Belongs to the JTB family. -
Cellular localization
Membrane. Mitochondrion. Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab183230 has not yet been referenced specifically in any publications.