The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Brain serine protease 1
Kallikrein 8 (neuropsin/ovasin)
Kallikrein related peptidase 8
KLK8 protein type 1
KLK8 protein type 2
neuropsin type 1
Neuropsin type 1, included
Neuropsin type 2
Neuropsin type 2, included
Neuropsin, mouse, homolog of
Protease serine 19
Serine protease 19
Serine protease kallikrein
Serine protease kallikrein/ovasin/neuropsin
Serine protease TADG 14
Serine protease TADG-14
Serine protease TADG14
Tumor associated differentially expressed gene 14
Tumor associated differentially expressed gene 14 protein
Tumor-associated differentially expressed gene 14 protein
Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.
Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes.
Belongs to the peptidase S1 family. Kallikrein subfamily. Contains 1 peptidase S1 domain.
Secreted. Cytoplasm. Shows a cytoplasmic distribution in the keratinocytes.