GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2
GCN5 general control of amino-acid synthesis 5-like 2 (yeast)
general control of amino acid synthesis 5-like 2
General control of amino acid synthesis protein 5-like 2
General control of amino acid synthesis, yeast, homolog-like 2
Histone acetyltransferase GCN5
Histone acetyltransferase KAT2A
K(lysine) acetyltransferase 2A
Lysine acetyltransferase 2A
FunctionFunctions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Tissue specificityExpressed in all tissues tested, with most abundant expression in ovary.
Sequence similaritiesBelongs to the GCN5 family. Contains 1 bromo domain. Contains 1 N-acetyltransferase domain.