Recombinant human KAT2B / PCAF protein (ab62629)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids352 to 658

Specifications

Our Abpromise guarantee covers the use of ab62629 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Purity> 95 % SDS-PAGE.

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • ReconstitutionReconstitute in MilliQ water to a concentration of 1 mg/ml. The solution can then be used in bioassay, or store at -20oC for future use

General Info

  • Alternative names
    • CAF
    • CREBBP associated factor
    • GCN5
    • GCN5L
    • GCN5L1
    • Histone acetylase PCAF
    • Histone acetyltransferase KAT2B
    • Histone acetyltransferase PCAF
    • K(lysine) acetyltransferase 2B
    • KAT2B
    • KAT2B_HUMAN
    • Lysine acetyltransferase 2B
    • P
    • P/CAF
    • p300/CBP associated factor
    • P300/CBP-associated factor
    • Pcaf
    see all
  • FunctionFunctions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
  • Tissue specificityUbiquitously expressed but most abundant in heart and skeletal muscle.
  • Sequence similaritiesBelongs to the GCN5 family.
    Contains 1 bromo domain.
    Contains 1 N-acetyltransferase domain.
  • DomainThe bromodomain mediates binding to HIV-1 Tat.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Recombinant human KAT2B / PCAF protein (ab62629)

ab62629 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your inquiry.

The HAT that we had (older lots) had an N-terminal His-tag. We are in the process of manufacturing a newer lot and at this point we do not know if there would be a His-tag on it or not for future lots.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"