Recombinant Human KAT2B / PCAF protein (ab82074)

Overview

Description

  • Nature
    Recombinant
  • Source
    Baculovirus
  • Amino Acid Sequence
    • Species
      Human

Associated products

Specifications

Our Abpromise guarantee covers the use of ab82074 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    1 unit equals 1 nanogram of purified protein.
  • Applications

    EMSA

  • Form
    Liquid
  • Additional notes
    1 unit equals 1 nanogram of purified protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8

General Info

  • Alternative names
    • CAF
    • CREBBP associated factor
    • GCN5
    • GCN5L
    • GCN5L1
    • Histone acetylase PCAF
    • Histone acetyltransferase KAT2B
    • Histone acetyltransferase PCAF
    • K(lysine) acetyltransferase 2B
    • KAT2B
    • KAT2B_HUMAN
    • Lysine acetyltransferase 2B
    • P
    • P/CAF
    • p300/CBP associated factor
    • P300/CBP-associated factor
    • Pcaf
    see all
  • Function
    Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
  • Tissue specificity
    Ubiquitously expressed but most abundant in heart and skeletal muscle.
  • Sequence similarities
    Belongs to the GCN5 family.
    Contains 1 bromo domain.
    Contains 1 N-acetyltransferase domain.
  • Domain
    The bromodomain mediates binding to HIV-1 Tat.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References

ab82074 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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