Recombinant Human KAT3A / CBP protein (ab56272)



  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids1319 to 1710


Our Abpromise guarantee covers the use of ab56272 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications


  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5

General Info

  • Alternative names
    • CBP
    • CREB binding protein
    • CREB-binding protein
    • Crebbp
    • Cyclic AMP responsive enhancer binding protein
    • KAT3A
    • RSTS
    • RTS
    • Rubinstein Taybi syndrome
    see all
  • FunctionAcetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 coactivator. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.
  • Involvement in diseaseNote=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with MYST3/MOZ; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with MYST4/MORF. MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.
    Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:180849]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.
  • Sequence similaritiesContains 1 bromo domain.
    Contains 1 KIX domain.
    Contains 2 TAZ-type zinc fingers.
    Contains 1 ZZ-type zinc finger.
  • DomainThe KIX domain mediates binding to HIV-1 Tat.
  • Post-translational
    Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response.
    Phosphorylated upon DNA damage, probably by ATM or ATR.
    Sumoylation negatively regulates transcriptional activity via the recruitment of DAAX.
  • Cellular localizationCytoplasm. Nucleus. Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.
  • Information by UniProt

Recombinant Human KAT3A / CBP protein images

  • ab56272 on SDS-PAGE.

References for Recombinant Human KAT3A / CBP protein (ab56272)

ab56272 has not yet been referenced specifically in any publications.

Product Wall

Vielen Dank für Ihren Anruf und Ihre Geduld.

Zu meiner großen Überraschung erhielt ich heute dann doch einmal eine Rückmeldung von dem Labor bezüglich des verpatzten Proteins: Die Verwirrung entstand anhand eines Date...

Read More

Ich freue mich Ihnen nun mitteilen zu können dass wir das DTT freie KAT3A / CBP Protein nun im Katalog haben:

ab135297 (or use the following:

Read More

Vielen Dank für Ihren Anruf.

Bitte entschuldigen Sie die Verzögerung in meiner Antwort.

Wir sind momentan dabei das KAT3A / CBP Protein ohne DTT in unseren Katalog aufzunehmen.

Ich werde Sie mit der Artikelnummer...

Read More