Overview

  • Product name
    Recombinant Human KCNH1 protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      RLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKA LNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQSPESERDIFGA
    • Molecular weight
      37 kDa including tags
    • Amino acids
      890 to 988

Specifications

Our Abpromise guarantee covers the use of ab116850 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • EAG
    • EAG channel 1
    • EAG1
    • Ether a go go potassium channel 1
    • Ether a go go, Drosophila, homolog of
    • Ether-a-go-go potassium channel 1
    • ether-a-go-go, Drosophila, homolog of
    • h eag
    • h-eag
    • hEAG1
    • Kcnh1
    • KCNH1_HUMAN
    • Kv10.1
    • M eag
    • MGC124419
    • MGC124420
    • MGC142269
    • Potassium voltage gated channel subfamily H (eag related), member 1
    • Potassium voltage gated channel subfamily H member 1
    • Potassium voltage-gated channel subfamily H member 1
    • Voltage gated potassium channel subunit Kv10.1
    • Voltage-gated potassium channel subunit Kv10.1
    see all
  • Function
    Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts.
  • Tissue specificity
    Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.
  • Sequence similarities
    Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.1/KCNH1 sub-subfamily.
    Contains 1 cyclic nucleotide-binding domain.
    Contains 1 PAC (PAS-associated C-terminal) domain.
    Contains 1 PAS (PER-ARNT-SIM) domain.
  • Domain
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Cellular localization
    Membrane.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE stained with Coomassie Blue showing ab116850 at approximately 36.52 kDa.

References

ab116850 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab116850.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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