The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Cardiac ATP sensitive potassium channel
Cardiac inward rectifier
G protein activated inward rectifier potassium channel 4
G protein-activated inward rectifier potassium channel 4
Heart KATP channel
Inward rectifier K(+) channel Kir3.4
Inward rectifier K+ channel KIR3.4
Inward rectifier potassium channel KIR3.4
inwardly rectifying subfamily J member 5
Potassium channel inwardly rectifying subfamily J member 5
Potassium inwardly rectifying channel J5
Potassium inwardly rectifying channel subfamily J member 5
potassium voltage-gated channel subfamily J member 5
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.
Islets, exocrine pancreas and heart.
Involvement in disease
Defects in KCNJ5 are the cause of long QT syndrome type 13 (LQT13) [MIM:613485]. It is a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.