Overview

  • Product name
    Recombinant Human KCNJ5 protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      SYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTPSCCAKELAEM KREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV
    • Amino acids
      321 to 419
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab158786 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Cardiac ATP sensitive potassium channel
    • Cardiac inward rectifier
    • CIR
    • G protein activated inward rectifier potassium channel 4
    • G protein-activated inward rectifier potassium channel 4
    • GIRK 4
    • GIRK-4
    • GIRK4
    • Heart KATP channel
    • Inward rectifier K(+) channel Kir3.4
    • Inward rectifier K+ channel KIR3.4
    • Inward rectifier potassium channel KIR3.4
    • inwardly rectifying subfamily J member 5
    • IRK-4
    • IRK5_HUMAN
    • KATP 1
    • KATP-1
    • KATP1
    • KCNJ 5
    • Kcnj5
    • KIR 3.4
    • KIR3.4
    • LQT13
    • Potassium channel
    • Potassium channel inwardly rectifying subfamily J member 5
    • Potassium inwardly rectifying channel J5
    • Potassium inwardly rectifying channel subfamily J member 5
    • potassium voltage-gated channel subfamily J member 5
    see all
  • Function
    This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.
  • Tissue specificity
    Islets, exocrine pancreas and heart.
  • Involvement in disease
    Defects in KCNJ5 are the cause of long QT syndrome type 13 (LQT13) [MIM:613485]. It is a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.
  • Sequence similarities
    Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
  • Cellular localization
    Membrane.
  • Information by UniProt

Images

  • ab158786 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab158786 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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