The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Cancer/testis antigen 31
Histone demethylase JARID1B
Jumonji AT rich interactive domain 1B
Jumonji/ARID domain-containing protein 1B
Lysine (K) specific demethylase 5B
Lysine demethylase 5B
Lysine specific demethylase 5B
Lysine-specific demethylase 5B
Protein phosphatase 1 regulatory subunit 98
putative DNA/chromatin binding motif
Retinoblastoma-binding protein 2 homolog 1
Retinoblastoma-binding protein 2 homolog 1A
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.
Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level).