This product is an active protein and may elicit a biological response in vivo, handle with caution.
Cancer/testis antigen 31
Histone demethylase JARID1B
Jumonji AT rich interactive domain 1B
Jumonji/ARID domain-containing protein 1B
Lysine (K) specific demethylase 5B
Lysine demethylase 5B
Lysine specific demethylase 5B
Lysine-specific demethylase 5B
Protein phosphatase 1 regulatory subunit 98
putative DNA/chromatin binding motif
Retinoblastoma-binding protein 2 homolog 1
Retinoblastoma-binding protein 2 homolog 1A
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.
Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level).