Recombinant Human KDM5C / Jarid1C / SMCX protein (ab125608)

Overview

Description

  • NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • AccessionP41229
    • SpeciesHuman
    • Molecular weight118 kDa including tags
    • Amino acids1 to 671
    • TagsGST tag N-Terminus

Associated products

Specifications

Our Abpromise guarantee covers the use of ab125608 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names
    • DXS1272E
    • Histone demethylase JARID1C
    • JARID1C
    • JmjC domain containing protein SMCX
    • Jumonji AT rich interactive domain 1C
    • Jumonji, AT rich interactive domain 1C (RBP2 like)
    • Jumonji/ARID domain-containing protein 1C
    • KDM5C
    • KDM5C_HUMAN
    • Lysine (K) specific demethylase 5C
    • Lysine-specific demethylase 5C
    • MRX13
    • MRXJ
    • MRXSCJ
    • MRXSJ
    • Protein SmcX
    • Protein Xe169
    • rbp2 like protein
    • Selected cDNA on X
    • SMCX
    • Smcx homolog X chromosome
    • SmcX protein
    • Smcy homolog X linked
    • XE169
    • Xe169 protein
    see all
  • FunctionHistone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements.
  • Tissue specificityExpressed in all tissues examined. Highest levels found in brain and skeletal muscle.
  • Involvement in diseaseDefects in KDM5C are the cause of mental retardation syndromic X-linked JARID1C-related (MRXSJ) [MIM:300534]. MRXSJ is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRXSJ patients manifest mental retardation associated with variable features such as slowly progressive spastic paraplegia, seizures, facial dysmorphism.
  • Sequence similaritiesBelongs to the JARID1 histone demethylase family.
    Contains 1 ARID domain.
    Contains 1 JmjC domain.
    Contains 1 JmjN domain.
    Contains 2 PHD-type zinc fingers.
  • DomainThe first PHD-type zinc finger domain recognizes and binds H3-K9Me3.
    Both the JmjC domain and the JmjN domain are required for enzymatic activity.
  • Cellular localizationNucleus.
  • Information by UniProt

Recombinant Human KDM5C / Jarid1C / SMCX protein images

  • SDS-PAGE analysis of ab125608.

References for Recombinant Human KDM5C / Jarid1C / SMCX protein (ab125608)

ab125608 has not yet been referenced specifically in any publications.

Product Wall



Unfortunately, ab125608will show no activityas the storage buffer is not suitable for this purpose. In addition, it is a fragment, not the full length protein.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"